[Chemical constituents from roots of Isatis indigotica]

Ye Chen; Chun-Lin Fan; Ying Wang; Xiao-Qi Zhang; Xiao-Jun Huang; Wen-Cai Ye

doi:10.19540/j.cnki.cjcmm.20180116.001

[Chemical constituents from roots of Isatis indigotica]

Zhongguo Zhong Yao Za Zhi. 2018 May;43(10):2091-2096. doi: 10.19540/j.cnki.cjcmm.20180116.001.

[Article in Chinese]

Authors

Ye Chen^{1

2}, Chun-Lin Fan^{1

2}, Ying Wang^{1

2}, Xiao-Qi Zhang^{1

2}, Xiao-Jun Huang^{1

2}, Wen-Cai Ye^{1

2}

Affiliations

¹ Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
² Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.

PMID: 29933676
DOI: 10.19540/j.cnki.cjcmm.20180116.001

Abstract

Nineteen compounds were isolated from the roots of Isatis indigotica through silica gel, Sephadex LH-20, ODS and pre-HPLC chromatography technique. Their structures were elucidated by the MS and NMR spectra as 7-hydroxydeoxyvasicinone (1), (1H-indol-3-yl) oxoacetamide (2), 1-methoxy-1H-indole-3-acetonitrile (3), arvelexin (4), 1H-indole-3-acetonitrile (5), 1H-indole-3-aldehyde (6), 1H-indole-3-acetic acid (7), 2,3-dihydro-4-hydroxy-2-oxo-indole-3-acetonitrile (8), deoxyvasicinone (9), indigotiisocoumarin A (10), cycloanthranilylproline (11), quinazoline-2,4(1H,3H)-diones (12), indirubin(13), (+)-pinoresinol (14), (+)-epipinoresinol (15), burselignan (16), (+)-isolariciresinol (17),vanillic acid (18) and 5-hydroxymaltol (19). Among them, compound 1 is a new natural product, and compound 2, 14, 15, 18 and 19 were isolated from the title plant for the first time.

Keywords: Isatis indigotica; chemical constituent; structural elucidation.

MeSH terms

Isatis / chemistry*
Phytochemicals / analysis*
Plant Roots / chemistry*

Substances

Phytochemicals