Effects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetes

Gynecol Endocrinol. 2018 Dec;34(12):1059-1063. doi: 10.1080/09513590.2018.1481944. Epub 2018 Jun 22.

Abstract
in En , Chinese

Patients with type 2 diabetes mellitus (T2DM) have been known to be suffering from coenzyme Q10 (CoQ10) deficiency which results in some complications in them. The purpose of this clinical trial study was to evaluate the effects of CoQ10 supplementation on serum values of adiponectin (A), leptin (L), 8-isoprostane, malondialdehyde (MDA), the A/L ratio in women with T2DM. Sixty-eight women with T2DM were enrolled in the current study and were randomly divided into drug (n = 34) and placebo (n = 34) groups who were consuming 100 mg CoQ10 and 100 mg cellulose acetate per day for 12 weeks, respectively. Measurements were performed at the beginning and after the intervention. Serum values of adiponectin (p = .001) and the A/L ratio (p = .001) were increased while values of leptin (p = .041), MDA (p = .023), 8-isoprostane (p = .004) were decreased significantly in drug group after intervention. This study had shown that CoQ10 supplementation in women with T2DM was effective in elevation of adiponectin and the A/L ratio and reduction of leptin, MDA and 8-isoprostane which could result in improving insulin resistance and modulating oxidative stress situation.

摘要 患有2型糖尿病(T2DM)的患者伴有辅酶Q10(CoQ10)缺乏, 这将导致一系列并发症。该临床试验研究的目的是评估补充CoQ10对2型糖尿病(T2DM)女性患者的脂联素(A), 瘦素(L), 8-异前列烷, 丙二醛(MDA), A/L比值的影响。本研究纳入了68名T2DM女性, 随机分为药物组(n = 34)和安慰剂组(n = 34), 每天服用100mg辅酶Q10和100mg醋酸纤维素, 共12周。在开始时和干预后对观察指标进行测量。干预后药物组患者的脂联素(p = .001)和A/L比(p = .001)的血清值增加, 瘦素(p = .041), MDA(p = .023), 8-异前列烷(p = .004)显著下降。本研究表明补充CoQ10对T2DM女性有效, 可提高脂联素和A/L比值, 减少瘦素, MDA和8-异前列烷, 从而改善胰岛素抵抗, 调节氧化应激状态。.

Keywords: Type 2 diabetes; adiponectin; coenzyme Q10; leptin; oxidative stress.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiponectin / blood
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Dietary Supplements
  • Dinoprost / analogs & derivatives
  • Dinoprost / blood
  • Double-Blind Method
  • Female
  • Humans
  • Leptin / blood
  • Malondialdehyde / blood
  • Middle Aged
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / therapeutic use
  • Vitamins / therapeutic use*

Substances

  • Adiponectin
  • Leptin
  • Vitamins
  • Ubiquinone
  • 8-epi-prostaglandin F2alpha
  • Malondialdehyde
  • Dinoprost
  • coenzyme Q10