Revealing the Genetic Instructions for Nervous System Wiring

Trends Neurosci. 2018 Jul;41(7):407-409. doi: 10.1016/j.tins.2018.04.008.


Why did the axon cross the midline? A 1993 paper by Corey Goodman and colleagues described a genetic screen in fruit flies that pioneered the discovery of conserved families of axon guidance cues and receptors, highlighting fundamental processes underlying wiring specificity in the developing nervous system.

Keywords: Drosophila; axon guidance; comm; midline; robo; slit.