The net effect of ANCA on neutrophil extracellular trap formation

Kidney Int. 2018 Jul;94(1):14-16. doi: 10.1016/j.kint.2018.03.010.


The formation of neutrophil extracellular traps induced by antineutrophil cytoplasmic autoantibodies has been implicated in the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis. Kraaij et al. now provide evidence that excessive neutrophil extracellular trap formation in vitro induced by sera from patients with antineutrophil cytoplasmic autoantibody-associated vasculitis is associated with active disease but is not dependent on the presence of antineutrophil cytoplasmic autoantibodies.

Publication types

  • Comment

MeSH terms

  • Animals
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / blood*
  • Antibodies, Antineutrophil Cytoplasmic / blood
  • Autoantibodies
  • Extracellular Traps / immunology*
  • Humans
  • Neutrophils / drug effects


  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies