IgA nephropathy: new insights into the role of complement

Kidney Int. 2018 Jul;94(1):16-18. doi: 10.1016/j.kint.2018.03.009.


Glomerular complement deposition is common in IgA nephropathy, and recent genome-wide association studies point to a role of complement factor H and complement factor H-related proteins in disease susceptibility. A number of recent studies have now documented elevated levels of some factor H-related proteins in IgA nephropathy, which might contribute to enhanced complement activation.

Publication types

  • Comment

MeSH terms

  • Complement Activation
  • Complement Factor H / genetics
  • Complement System Proteins / genetics
  • Genome-Wide Association Study
  • Glomerulonephritis, IGA*
  • Humans


  • Complement Factor H
  • Complement System Proteins