EVLP: Ready for Prime Time?

Semin Thorac Cardiovasc Surg. Spring 2019;31(1):1-6. doi: 10.1053/j.semtcvs.2018.05.005. Epub 2018 Jun 21.

Abstract

Ex vivo lung perfusion implies perfusion and ventilation of a donor lung outside of the human body. The 2 most clinically relevant and commercially available devices currently in clinical trials are XVIVO Perfusion System (XPS Perfusion, Goteborg, Sweden) and Organ Care System (Transmedics, Andover, MA). Our review focuses on the needs met by ex vivo lung perfusion, and the clinical literature on both devices.

Keywords: End stage lung disease; Ex vivo lung perfusion; Lung transplantation.

Publication types

  • Review

MeSH terms

  • Donor Selection
  • Equipment Design
  • Graft Survival
  • Humans
  • Lung Transplantation / adverse effects
  • Lung Transplantation / instrumentation
  • Lung Transplantation / methods*
  • Lung Transplantation / mortality
  • Organ Preservation / adverse effects
  • Organ Preservation / instrumentation
  • Organ Preservation / methods*
  • Organ Preservation / mortality
  • Perfusion / adverse effects
  • Perfusion / instrumentation
  • Perfusion / methods*
  • Perfusion / mortality
  • Pneumonectomy* / adverse effects
  • Primary Graft Dysfunction / etiology
  • Primary Graft Dysfunction / physiopathology
  • Primary Graft Dysfunction / prevention & control
  • Respiration, Artificial / adverse effects
  • Respiration, Artificial / instrumentation
  • Respiration, Artificial / methods*
  • Respiration, Artificial / mortality
  • Risk Factors
  • Temperature
  • Time Factors
  • Tissue and Organ Harvesting* / adverse effects
  • Treatment Outcome
  • Ventilators, Mechanical