Multi-effects of Resveratrol on stem cell characteristics: Effective dose, time, cell culture conditions and cell type-specific responses of stem cells to Resveratrol

Eur J Med Chem. 2018 Jul 15;155:651-657. doi: 10.1016/j.ejmech.2018.06.037. Epub 2018 Jun 18.


Stem cells which defined by dual features of self-renewal and differentiation potential provide a unique source for repairing damaged tissues to treat a wide spectrum of diseases and injuries. Several recent studies suggest that Resveratrol (RSV), a natural polyphenol component, possesses the ability to improve either culture conditions of stem cells or their target differentiation in culture. This review covers the literature that deals with the effects of RSV and its underlying mechanisms on survival, self-renewal and lineage commitment of various stem cells. Concentration of RSV and duration of treatment with this component could exert differential effects on cellular differentiation processes and cell fate. Therefore, RSV could be accounted as an effective small molecule for a variety of cell therapies which should be implemented by a special care considering, effective concentration and duration of exposure.

Keywords: Cardiac differentiation; Neural differentiation; Osteogenesis; Proliferation; Resveratrol; Self renewal.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Molecular Structure
  • Resveratrol
  • Stem Cell Transplantation
  • Stem Cells / drug effects*
  • Stilbenes / chemistry
  • Stilbenes / pharmacology*
  • Structure-Activity Relationship


  • Stilbenes
  • Resveratrol