Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation

J Allergy Clin Immunol. 2018 Oct;142(4):1355-1358. doi: 10.1016/j.jaci.2018.06.014. Epub 2018 Jun 21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angioedema / drug therapy
  • Animals
  • Antibodies, Blocking / pharmacology*
  • Antibodies, Blocking / therapeutic use
  • Bradykinin / blood*
  • Complement C1 Inhibitor Protein / genetics
  • Factor XII / immunology*
  • Humans
  • Macaca fascicularis
  • Male
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Passive Cutaneous Anaphylaxis / drug effects

Substances

  • Antibodies, Blocking
  • Complement C1 Inhibitor Protein
  • Factor XII
  • Bradykinin