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Review
. 2018 Jun 25;19(6):1431-1437.
doi: 10.22034/APJCP.2018.19.6.1431.

The Association Between Selenium and Prostate Cancer: A Systematic Review and Meta-Analysis

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Free PMC article
Review

The Association Between Selenium and Prostate Cancer: A Systematic Review and Meta-Analysis

Kourosh Sayehmiri et al. Asian Pac J Cancer Prev. .
Free PMC article

Abstract

Background: Evidence of relationship between selenium and prostate cancer has been inconsistent. The present metaanalysis was conducted to determine relationship between selenium and prostate cancer. Methods: A systematic review and meta-analysis was carried out using preferred reporting items for systematic reviews and meta-analysis (PRISMA). We searched PubMed, Scopus, Web of Science, ScienceDirect, Embase, CINAHL, Cochrane Library, EBSCO and Google scholar search engines and the reference lists of the retrieved papers for relevant data, without any limitation regarding language or time until 2016. Heterogeneity among studies was evaluated using Q test and I2 Index. Finally, a random effects model was used for combining results using STATA software version 11.1. P<0.05 was considered significant. Results: Thirty-eight studies including 36,419 cases and 105,293 controls were included in the final analysis. The pooled relative risk (RR) of relation between selenium and prostate cancer was 0.86 (95% Confidence Interval [CI]:0.78-0.94). Sub-group analyses based on case-control, cohort, and RCT studies gave values of 0.89 (95% CI: 0.80-1.00), 0.77 (95% CI: 0.52-1.14) and 0.90 (95% CI: 0.74-1.09), respectively. RRs based on serum, plasma and nail samples were 0.69 (95% CI: 0.51-0.95), 0.85 (95% CI: 0.61-1.17), 0.66 (95% CI: 0.41-1.05), respectively. According to 10 studies, investigated the relation between advanced prostate cancer and selenium in which the RR was 0.67 (95% CI: 0.52-0.87). Conclusions: This meta-analysis indicated that selenium most probably has a protective role against development of prostate cancer and its progression to advanced stages. Therefore, selenium supplementation can be proposed for prevention of prostate cancer.

Keywords: Selenium; prostate cancer; meta-analysis.

Figures

Figure 1
Figure 1
The Entrance Steps of Systematic Review and Meta- Analysis
Figure 2
Figure 2
Data Analysis of studies about the Relation between Selenium and Prostate Cancer. Mean point of each segment shows the estimation of Relative Risk (RR) and the length of each segment showed the 95% confidential interval in each study. The diamond mark shows the RR of each study.
Figure 3
Figure 3
Cumulative Forest Plot in the Meta-Analysis of Studies about the Relation between Selenium and Prostate Cancer.
Figure 4
Figure 4
Meta- Analysis of Studies about the Relation between Selenium and Advanced Prostate Cancer

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