The Value of Outbred Rodent Models in Cancer Research

Trends Cancer. 2018 Jul;4(7):468-471. doi: 10.1016/j.trecan.2018.05.004. Epub 2018 Jun 7.


Mouse models of breast cancer are valuable research tools, but their usefulness is restricted by a series of features inherent to their physiology, such as low endogenous estrogens and genetics (inbred status). Depending on the specific questions asked, outbred rodents like Peromyscus may provide answers that laboratory mice cannot.

Keywords: hormone-sensitive breast cancer; host diversity; outbred model; xenograft.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Animals, Outbred Strains*
  • Biomedical Research*
  • Humans
  • Mice
  • Neoplasms*
  • Peromyscus