Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 13 (1), 10-15

Assessment of Auditory Functions in Chronic Hepatitis C Patients Treated by Sofosbuvir


Assessment of Auditory Functions in Chronic Hepatitis C Patients Treated by Sofosbuvir

Elshahat Ibrahem Ismail et al. J Otol.


Objective: Evaluating the auditory function in patients with chronic hepatitis C treated with sofosbuvir and ribavirin.

Methods: This study involved 80 patients with chronic hepatitis C who agreed to receive sofosbuvir and ribavirin. All participants were subjected to baseline otological and audiological assessment just before treatment. The audiological assessment included standard pure tone audiometry, extended high-frequency audiometry, immitancemetry and otoacoustic emissions (OAEs) (transient and distortion product). According to baseline hearing threshold measurements, the study population was divided into 2 groups. Group 1 included 42 patients with normal hearing sensitivity (250-8000 Hz), and Group 2 included 38 patients with sensorineural hearing loss. After 24 weeks of therapy, otological and audiological assessments were repeated and compared between the two groups and before and after therapy.

Results: Post-treatment hearing threshold evaluation showed no significant difference from pretreatment evaluation at all tested frequencies. There was no statistically significant difference between pre and post-treatment otoacoustic emissions results.

Conclusion: Therapy with sofosbuvir and ribavirin in chronic hepatitis C has no noticeable effects on cochlear functions.

Keywords: Auditory functions; Chronic hepatitis C; Otoacoustic emission; Sofosbuvir.

Similar articles

See all similar articles


    1. Asal S., Sobhy O., Ismail O., Bedewy E. Study of the effect of combined interferon and ribavirin therapy on the hearing profile of hepatitis C virus patients. Egypt J. Otolaryngol. 2015;31:237–243.
    1. Baradarnfar M.H., Karamifar K., Mehrparvar A.H., Mollasadeghi A., Gharavi M., Karimi G. Amplitude changes in otoacoustic emissions after exposure to industrial noise. Noise Health. 2012;14(56):28–31. - PubMed
    1. Berenguer M., Lopez-Labrador F., Wright T. Hepatitis C and liver transplantation. J. Hepatol. 2001;35:666–678. - PubMed
    1. Bisht M., Bist S.S. Ototoxicity: the hidden menace. Indian J. Otolaryngol. Head Neck Surg. 2011;63:255–259. - PMC - PubMed
    1. European Association for the Study of the Liver 2011 European association of the study of the liver hepatitis C virus clinical practice guidelines. Liver Int. 2012;32(1):2–8. - PubMed