Medical Cannabis in Patients with Chronic Pain: Effect on Pain Relief, Pain Disability, and Psychological aspects. A Prospective Non randomized Single Arm Clinical Trial

Clin Ter. May-Jun 2018;169(3):e102-e107. doi: 10.7417/T.2018.2062.

Abstract

Background: There is an increasing interest in the medical use of cannabis, particularly in the treatment of chronic pain.

Objectives: The aim is to evaluate the effects of cannabis use and the associated benefits reported by patients with various chronic pain diagnoses.

Material and methods: A total of 338 patients with different chro- nic pain conditions were treated with a Cannabis Flos 19% decoction for 12 months, in addition to their pharmacological therapy. Baseline levels for pain medications, pain intensity, pain disability, anxiety and depression were recorded at 1, 3, 6 and 12 months.

Results: Pain intensity records a statistically significant reduction from Baseline to 12 months follow up (X² 61.375; P<0,001); the im- provements from Baseline to 12 months follow up are also recorded in pain disability (X² 39.423; P<0,001) and in anxiety and depression symptoms (X²30.362; P<0,001; X²27.786; P<0,001).

Conclusions: Our study suggest that Cannabis therapy, as an adjun- ct a traditional analgesic therapy, can be an efficacious tool to make more effective the management of chronic pain and its consequences on functional and psychological dimension. Further randomized, controlled trials are needed to confirm our conclusions.

Keywords: Anxiety; Chronic Pain; Depression; Medical Cannabis; Pain Disability.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anxiety / epidemiology
  • Chronic Pain / drug therapy*
  • Depression / epidemiology
  • Female
  • Humans
  • Male
  • Medical Marijuana / administration & dosage*
  • Middle Aged
  • Pain Management / methods*
  • Prospective Studies
  • Young Adult

Substances

  • Medical Marijuana