Lambert-Eaton Myasthenic Syndrome

Excerpt

Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular junction disorder that may present as a paraneoplastic syndrome or a primary autoimmune disorder. The majority of cases are associated with small-cell lung cancer (SCLC). The primary clinical symptom is muscle weakness. The underlying pathophysiology involves the development of antibodies that target voltage-gated calcium channels (VGCCs) on presynaptic nerve terminals, resulting in reduced acetylcholine (ACh) neurotransmitter release. This activity reviews the pathogenesis, diagnostic procedures, and treatment strategies for LEMS.