Zonisamide is a sulfonamide antiepileptic drug that is chemically distinct from other antiepileptic medications. As a 1,2-benzisoxazole derivative, it may be indicated for both epileptic and non-epileptic conditions. This activity reviews the indications, administration, contraindications, and precautions associated with zonisamide use. The mechanism of action, pharmacokinetics, associated adverse reactions, and monitoring strategies are analyzed to enhance clinical decision-making. Drug-drug interactions and clinical toxicology are also discussed to support safe and effective prescribing practices.
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