miR-129-5p suppresses breast cancer proliferation by targeting CBX4

Neoplasma. 2018;65(4):572-578. doi: 10.4149/neo_2018_170814N530.


Deregulation of microRNA (miRNA) is closely related to cancer development and progression. Our previous study identified that miR-129-5p suppresses proliferation and metastasis in breast cancer cells. Herein, we determined that CBX4 is a miR-129-5p target gene. CBX4 is up-regulated in breast cancer tissues and while its over-expression promotes cell proliferation, its knockdown suppresses cell proliferation in breast cancer cells. Furthermore, CBX4 mediates miR-129-5p-induced inhibition of cell proliferation and negatively correlates with the expression of miR-129-5p expression. These combined results suggest that CBX4 is an oncogene in breast cancer cells, and that it may provide a novel therapeutic strategy for breast cancer treatment.

Keywords: CBX4; miR-129-5p; proliferation breast cancer..

MeSH terms

  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Ligases / genetics*
  • MicroRNAs / genetics*
  • Polycomb-Group Proteins / genetics*


  • MicroRNAs
  • Mirn129 microRNA, human
  • Polycomb-Group Proteins
  • Ligases
  • CBX4 protein, human