Parkinson's disease-associated protein Parkin: an unusual player in cancer

Cancer Commun (Lond). 2018 Jun 26;38(1):40. doi: 10.1186/s40880-018-0314-z.

Abstract

The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.

Keywords: Cancer; E3 ubiquitin ligase; Parkin; Parkinson’s disease; Tumor suppressor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis / genetics
  • Cell Proliferation / genetics
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Mitophagy / genetics
  • Mutation*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Parkinson Disease / genetics*
  • Parkinson Disease / metabolism
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / metabolism
  • Ubiquitin-Protein Ligases / genetics*
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Tumor Suppressor Proteins
  • Ubiquitin-Protein Ligases
  • parkin protein