Tea Consumption and Longitudinal Change in High-Density Lipoprotein Cholesterol Concentration in Chinese Adults

J Am Heart Assoc. 2018 Jun 25;7(13):e008814. doi: 10.1161/JAHA.118.008814.


Background: The relation between tea consumption and age-related changes in high-density lipoprotein cholesterol (HDL-C) concentrations remains unclear, and longitudinal human data are limited. The aim of current study was to examine the relation between tea intake and longitudinal change in HDL-C concentrations.

Methods and results: Baseline (2006) tea consumption was assessed via a questionnaire, and plasma HDL-C concentrations were measured in 2006, 2008, 2010, and 2012 among 80 182 individuals (49±12 years of age) who did not have cardiovascular diseases or cancer, or did not use cholesterol-lowering agents both at baseline (2006) and during the follow-up period (2006-2012). The associations between baseline tea consumption and rate of change in HDL-C concentrations were examined using generalized estimating equation models. Tea consumption was inversely associated with a decreased rate of HDL-C concentrations (P-trend <0.0001) in the fully adjusted model. The adjusted mean difference in the HDL-C decreased rate was 0.010 (95% confidence interval, 0.008, 0.012) mmol/L per year for tea consumers versus nonconsumers (never or less than once/month group). Interactions between tea consumption and age, sex, lifestyle scores, and metabolic syndrome (all P-interaction <0.0001) were identified. The associations between greater tea consumption and slower decrease in HDL-C concentrations were more pronounced in men, individuals aged 60 or older, individuals with a lower lifestyle score, and individuals with metabolic syndrome (all P-trend <0.0001).

Conclusions: Tea consumption was associated with slower age-related decreases in HDL-C concentrations during 6 years of follow-up.

Clinical trial registration: URL: www.chictr.org. Unique identifier: ChiCTR-TNRC-11001489.

Keywords: cardiovascular disease risk factors; catechins; high‐density lipoprotein cholesterol; lipids and lipoproteins; longitudinal cohort study; nutrition; polyphenols.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group
  • Biomarkers / blood
  • China
  • Cholesterol, HDL / blood*
  • Down-Regulation
  • Dyslipidemias / blood
  • Dyslipidemias / diagnosis
  • Dyslipidemias / ethnology
  • Dyslipidemias / prevention & control*
  • Female
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Prospective Studies
  • Protective Factors
  • Risk Factors
  • Risk Reduction Behavior
  • Tea*
  • Time Factors
  • Young Adult


  • Biomarkers
  • Cholesterol, HDL
  • Tea

Associated data

  • ChiCTR/ChiCTR‐TNRC‐11001489