Estimation of a Preference-Based Summary Score for the Patient-Reported Outcomes Measurement Information System: The PROMIS ®-Preference (PROPr) Scoring System

Med Decis Making. 2018 Aug;38(6):683-698. doi: 10.1177/0272989X18776637. Epub 2018 Jun 26.

Abstract

Background: Health-related quality of life (HRQL) preference-based scores are used to assess the health of populations and patients and for cost-effectiveness analyses. The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS®) consists of patient-reported outcome measures developed using item response theory. PROMIS is in need of a direct preference-based scoring system for assigning values to health states.

Objective: To produce societal preference-based scores for 7 PROMIS domains: Cognitive Function-Abilities, Depression, Fatigue, Pain Interference, Physical Function, Sleep Disturbance, and Ability to Participate in Social Roles and Activities.

Setting: Online survey of a US nationally representative sample ( n = 983).

Methods: Preferences for PROMIS health states were elicited with the standard gamble to obtain both single-attribute scoring functions for each of the 7 PROMIS domains and a multiplicative multiattribute utility (scoring) function.

Results: The 7 single-attribute scoring functions were fit using isotonic regression with linear interpolation. The multiplicative multiattribute summary function estimates utilities for PROMIS multiattribute health states on a scale where 0 is the utility of being dead and 1 the utility of "full health." The lowest possible score is -0.022 (for a state viewed as worse than dead), and the highest possible score is 1.

Limitations: The online survey systematically excludes some subgroups, such as the visually impaired and illiterate.

Conclusions: A generic societal preference-based scoring system is now available for all studies using these 7 PROMIS health domains.

Keywords: PROMIS; US general population; health utility; health-related quality of life.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cost-Benefit Analysis
  • Decision Making
  • Decision Support Techniques
  • Fatigue / pathology
  • Female
  • Health Status*
  • Humans
  • Male
  • Mental Health
  • Mobility Limitation
  • Pain / pathology
  • Patient Preference*
  • Patient Reported Outcome Measures*
  • Quality of Life*
  • Sleep / physiology
  • Social Participation
  • Surveys and Questionnaires / standards*
  • United States