[Effect of modified Buzhong Yiqi decoction combined with pelvic floor muscle exercise-biofeedback-electrical stimulation on early stage postpartum pelvic floor dysfunction]

Zhongguo Zhong Yao Za Zhi. 2018 Jun;43(11):2391-2395. doi: 10.19540/j.cnki.cjcmm.20180305.001.
[Article in Chinese]

Abstract

To investigate the curative effect of modified Buzhong Yiqi decoction combined with pelvic floor muscle exercise-biofeedback-electrostimulation on early postpartum pelvic floor dysfunction disease (PFD) and its effect on the expression of transforming growth factor (TGF-β1), matrix metalloprotein (MMP-2), and tissue inhibitor of metalloproteinase (TIMP-2). A total of 186 PFD patients admitted to our hospital from March 2014 to December 2016 were selected in the study and were randomly divided into test group (n=93) and control group (n=93). The control group received pelvic floor muscle exercises-biofeedback-electrostimulation, while the test group was additionally treated with modified Buzhong Yiqi decoction based on the treatment in control group. Then the clinical efficacy was compared between two groups. The results showed that vaginal contractile electromyography (EMG), duration of vaginal constriction, dynamic vaginal pressure and pelvic floor myoelectric activity in the test group at 1, 3 and 6 months after treatment were significantly higher than those before treatment and the control group (P<0.05). The effective rate for urinary incontinence was 97.14% in test group, significantly higher than 75.68% in the control group (P<0.05). The effective rate for improvement of sexual life quality was 96.43% in test group, significantly higher than 74.07% in control group (P<0.05). 1, 3 and 6 months after treatment, the uterine prolapse, posterior wall prolapse and anterior wall prolapse grade in test group was slightly lower than that in the control group, but the difference was not statistically significant. After treatment, the levels of TGF-β1 and TIMP-2 in the test group were higher than those in the control group, while the levels of MMP-2 were lower than those in the control group (P<0.05). The results showed that modified Buzhong Yiqi decoction combined with pelvic floor muscle exercise-biofeedback-electrostimulation can effectively relieve the clinical symptoms, promote the body recovery and improve the quality of sexual life in PFD patients, with remarkable advantages, so it is worthy of popularizing.

Keywords: MMP-2; TGF-β1; TIMP-2; modified Buzhong Yiqi decoction; pelvic floor dysfunction disease.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Biofeedback, Psychology*
  • Drugs, Chinese Herbal / therapeutic use*
  • Electric Stimulation*
  • Exercise Therapy*
  • Female
  • Humans
  • Matrix Metalloproteinase 2 / metabolism
  • Pelvic Floor Disorders / therapy*
  • Postpartum Period
  • Tissue Inhibitor of Metalloproteinase-2 / metabolism
  • Transforming Growth Factor beta1 / metabolism

Substances

  • Drugs, Chinese Herbal
  • TGFB1 protein, human
  • TIMP2 protein, human
  • Transforming Growth Factor beta1
  • bu-zhong-yi-qi-tang
  • Tissue Inhibitor of Metalloproteinase-2
  • MMP2 protein, human
  • Matrix Metalloproteinase 2