Long-term survival after R0 resection of thymoma

Asian Cardiovasc Thorac Ann. 2018 Jul;26(6):461-466. doi: 10.1177/0218492318778634. Epub 2018 Jun 26.

Abstract

Background The aim of this study was to evaluate the results of R0 resection of thymoma to identify prognostic factors for long-term outcomes. Methods Data of 62 patients (28 male, 34 female) with a mean age of 47.26 ± 14.42 years, who underwent R0 resection for thymoma and were followed-up between February 2004 and March 2016, were analyzed retrospectively. Results Eight patients had a video-assisted thoracoscopic thymectomy and 54 had a transsternal extended thymectomy. During a mean follow-up of 128.67 ± 7.95 months, regional recurrence of thymoma was observed in 9 (14.5%) patients. Overall 5- and 10-year survival rates were 85.36% and 78.20%, respectively. The 5- and 10-year survival rates in patients aged < 50 years were significantly better than in those aged ≥ 50 years (92% and 72% vs. 88% and 39%, p < 0.0001). The 10-year overall survival of patients in Masaoka stage I and II was better than those in stage III (88.9%, 78.4%, 69.8%, respectively, log-rank p < 0.001). The 10-year survival of patients with World Health Organization histological type A, AB, and B1 thymomas was better than those with type B2 and B3 (log-rank test p < 0.001). In multivariate analysis, age < 50 years ( p = 0.001), Masaoka stage ( p = 0.006), histological type ( p = 0.001), and recurrence ( p = 0.04) were independent prognostic factors for survival. Conclusion Our study indicates that age < 50 years, Masaoka stage, histological type, and recurrence are the determinants of survival in surgically resected cases of thymoma.

Keywords: Age groups; Neoplasm recurrence; Neoplasm staging; Survival rate; Thymectomy; Thymoma; local.

MeSH terms

  • Female
  • Follow-Up Studies
  • Forecasting*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Retrospective Studies
  • Survival Rate / trends
  • Thoracic Surgery, Video-Assisted / methods*
  • Thymectomy / methods*
  • Thymoma / diagnosis
  • Thymoma / mortality
  • Thymoma / surgery*
  • Thymus Neoplasms / diagnosis
  • Thymus Neoplasms / mortality
  • Thymus Neoplasms / surgery*
  • Turkey / epidemiology