Dissecting the mammary gland one cell at a time

Nat Commun. 2018 Jun 26;9(1):2473. doi: 10.1038/s41467-018-04905-2.

Abstract

Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing to improve our understanding of the composition of the mammary epithelium at different developmental stages.

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cell Transformation, Neoplastic
  • Epithelial Cells / cytology
  • Female
  • Gene Expression Regulation, Developmental
  • Humans
  • Mammary Glands, Animal / cytology*
  • Mammary Glands, Animal / growth & development
  • Mammary Glands, Animal / metabolism
  • Mammary Glands, Human / cytology*
  • Mammary Glands, Human / growth & development
  • Mammary Glands, Human / metabolism
  • Mice
  • Models, Biological
  • Sequence Analysis, RNA
  • Stem Cells / cytology
  • Stem Cells / metabolism