Background: We investigated the distinguishing pathological features of bilateral ovarian tumors using magnetic resonance (MR) imaging.
Methods: Eighty-six patients with bilateral ovarian tumors on MR imaging were evaluated. The pathological diagnosis was investigated, and the results were subjected to statistical analysis using Mann-Whitney U test, Fisher's exact test, Chi-squared test and receiver operating characteristic (ROC) curve to determine the features useful for the differentiation of distinct types of lesions.
Results: The diagnosis of bilateral ovarian tumors was confirmed in eighty-one patients and the majority of the lesions were further classified into serous carcinoma (n = 36), mature teratoma (n = 20) and metastasis (n = 12). We assessed the existence of factors useful for the MR imaging differentiation between metastasis and serous carcinoma or primary malignant ovarian tumors. Cancer antigen (CA) 125 serum level and maximum tumor diameter were significantly different between metastasis and serous carcinoma and similarly, between metastasis and primary malignant ovarian tumors. MR imaging morphology, ascites and peritoneal implants did not show any significant difference between the different types of lesions.
Conclusion: Within our patient cohort, most bilateral ovarian tumor lesions were determined to be serous carcinoma, mature teratoma or metastasis. CA 125 serum level and maximum tumor diameter are useful markers for the differentiation between metastasis and serous carcinoma or primary malignant ovarian tumors.
Keywords: bilateral; cancer antigen 125; magnetic resonance imaging; maximum tumor diameter; ovarian tumor.
MRI for Discriminating Metastatic Ovarian Tumors From Primary Epithelial Ovarian CancersY Xu et al. J Ovarian Res 8, 61. PMID 26310488.Significant differences between metastatic ovarian tumors and primary epithelial ovarian cancers were found in the median age of patients, laterality, the maximum diamete …
Magnetic Resonance Imaging for Distinguishing Ovarian Clear Cell Carcinoma From High-Grade Serous CarcinomaFH Ma et al. J Ovarian Res 9 (1), 40. PMID 27377917.CCC typically showed an oval, unilocular cystic mass with large papillary projection and T1-hyperintense cystic components. MRI could be helpful for distinguishing CCC fr …
Clinical Factors and Biomarkers in Ovarian Tumors DevelopmentCD Vrabie et al. Rom J Morphol Embryol 49 (3), 327-38. PMID 18758637.Ovarian cancer is a disease difficult to detect in early stages due to nonspecific symptoms and has a rapid progression with frequent relapses after radical surgical proc …
Evidence for the Multifocal Origin of Bilateral and Advanced Human Serous Borderline Ovarian TumorsKH Lu et al. Cancer Res 58 (11), 2328-30. PMID 9622067.Borderline ovarian tumors (BOTs), or ovarian tumors of low malignant potential, represent a distinct category of epithelial ovarian neoplasms that have a clinically more …
Are All Pelvic (Nonuterine) Serous Carcinomas of Tubal Origin?CG Przybycin et al. Am J Surg Pathol 34 (10), 1407-16. PMID 20861711.It has been proposed that the presence of tubal intraepithelial carcinoma (TIC), in association with one-third to nearly half of pelvic serous carcinomas, is evidence of …