Evaluation of a radioimmunoassay for neuron specific enolase in small cell lung cancer

Br J Cancer. 1985 Sep;52(3):333-8. doi: 10.1038/bjc.1985.198.

Abstract

A radioimmunoassay for neuron specific enolase (NSE), a marker of neuroendocrine differentiation, has been evaluated in small cell lung cancer (SCLC). In untreated patients 25/38 (68%) with localized SCLC had raised blood levels of NSE (greater than 13 ng ml-1), in extensive disease 34/39 (87%) patients had raised NSE levels. In patients with non-small cell lung cancer (NSCLC) the serum levels were raised in 16/94 (17%). In extensive tumours of non-pulmonary origin NSE levels were increased in 24/116 (20%) patients. Longitudinal studies indicated a good correlation between the response to chemotherapy and fall of NSE levels. Tumour progression was accompanied by a rising NSE in 25/29 patients, with doubling times of 7-90 days. In patients with progression with a normal NSE the recurrence was a NSCLC. Cerebral metastases occurring as the only recurrence during clinical complete remission were not accompanied by a rise of NSE. Serum NSE levels provides a valuable monitor for SCLC during and after chemotherapy.

MeSH terms

  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / enzymology*
  • England
  • Humans
  • Longitudinal Studies
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / enzymology*
  • Phosphopyruvate Hydratase / blood*
  • Radioimmunoassay

Substances

  • Phosphopyruvate Hydratase