Benign prostatic hypertrophy: Pycnogenol® supplementation improves prostate symptoms and residual bladder volume

Minerva Med. 2018 Aug;109(4):280-284. doi: 10.23736/S0026-4806.18.05572-6.


Background: The aim of this study was to evaluate the efficacy of Pycnogenol® supplementation in terms of safety and tolerability in the setting of preclinical or borderline, initial symptoms of benign prostatic hyperthrophy (BPH), in otherwise healthy subjects, using Pycnogenol® over a period of 60 days.

Methods: Seventy-five healthy men with symptoms and signs of initial BPH were included. The subjects were divided into three groups: 1) control group using only the standard management (SM); 2) a group using SM plus Pycnogenol® 150 mg/day; 3) a group using standard pharmacological management.

Results: BPH symptoms like emptying, frequency, intermittency, urgency, weak flow, straining, nocturia, were all significantly improved with Pycnogenol® (P<0.05) and the difference with both control groups was statistically significant (P<0.05).

Conclusions: Pycnogenol® may be an important option for self-management of BPH in otherwise healthy men.

MeSH terms

  • Aged
  • Flavonoids / therapeutic use*
  • Humans
  • Male
  • Plant Extracts
  • Prostatic Hyperplasia / drug therapy*
  • Prostatic Hyperplasia / physiopathology*
  • Urinary Bladder / physiopathology*


  • Flavonoids
  • Plant Extracts
  • pycnogenols