Developmental and regional differences in the localization of Na,K-ATPase activity in the rabbit hippocampus

Brain Res. 1985 Sep 16;343(1):198-203. doi: 10.1016/0006-8993(85)91180-1.


Regional differences in Na,K-ATPase activity, and development of Na,K-ATPase activity were examined in rabbit hippocampus using a histochemical marker of enzyme activity. Stratum lucidum of CA3/CA2, corresponding to the mossy fiber terminal field, showed high Na,K-ATPase activity compared to stratum radiatum of CA1. A significant increase in Na,K-ATPase activity was found between 8 and 15 days postnatal. Tissues with limited Na,K-ATPase activity (immature hippocampus, the mature CA1 region) appear particularly prone to seizure-like abnormalities, perhaps reflecting an inability to regulate extracellular potassium.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Hippocampus / enzymology*
  • Histocytochemistry
  • Rabbits
  • Sodium-Potassium-Exchanging ATPase / metabolism*


  • Sodium-Potassium-Exchanging ATPase