Successful live birth in a patient who underwent cranial radiotherapy and systemic chemotherapy by implantation of a cryopreserved blastocyst on day 7

Clin Exp Obstet Gynecol. 2017;44(3):467-469.


Preservation of fertility has been recommended for cancer-bearing patients of reproductive age before undergoing cancer treatment. However, there are many considerations and it is difficult to preserve fertility for all patients undergoing therapy for malignancies. Female cancer survivors had lower pregnancy and live birth rates compared with others that underwent assisted reproductive technologies (ARTs). We should continue to consider the issue of infertility in patients who underwent therapies for malignancies. This is the first report of a successful live birth in a patient with a cranial tumor who underwent radiotherapy and chemotherapy after implantation of an autologous embryo. The patient was a 27-year-old Japanese woman. She was diagnosed with suprasellar germinoma at 13 years of age, and she developed panhypopituitarism after radiotherapy and chemotherapy. At 27 years of age, she began infertility treatment with in-vitro fertilization (IVF). The level of anti-Mallerian hormone (AMH) was 4.29 ng/ml. After ovarian stimulation by high purified human menopausal gonadotropin (HP-hMG), she obtained two blastocysts and became pregnant by implantation of a cryopre- served blastocyst. At 37 gestational weeks, she delivered a healthy female baby by cesarean section.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blastocyst
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / radiotherapy*
  • Cryopreservation
  • Embryo Implantation
  • Female
  • Fertilization in Vitro
  • Germinoma / drug therapy*
  • Germinoma / radiotherapy*
  • Humans
  • Live Birth
  • Ovulation Induction
  • Pregnancy
  • Reproductive Techniques, Assisted