Rodent models of AKI-CKD transition

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1098-F1106. doi: 10.1152/ajprenal.00199.2018. Epub 2018 Jun 27.


Acute kidney injury (AKI) is a contributing factor in the development and progression of chronic kidney disease (CKD). Despite rapid progresses, the mechanism underlying AKI-CKD transition remains largely unclear. Animal models recapitulating this process are crucial to the research of the pathophysiology of AKI-CKD transition and the development of effective therapeutics. In this review, we present the commonly used rodent models of AKI-CKD transition, including bilateral ischemia-reperfusion injury (IRI), unilateral IRI, unilateral IRI with contralateral nephrectomy, multiple episodes of IRI, and repeated treatment of low-dose cisplatin, diphtheria toxin, aristolochic acid, or folic acid. The main merits and pitfalls of these models are also discussed. This review provides helpful information for establishing reliable and clinically relevant models for studying post-AKI development of chronic renal pathologies and the progression to CKD.

Keywords: acute kidney injury; chronic kidney disease; cisplatin; fibrosis; ischemia; model; nephrotoxicity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Acute Kidney Injury / pathology*
  • Animals
  • Disease Models, Animal
  • Disease Progression
  • Humans
  • Kidney / pathology*
  • Renal Insufficiency, Chronic / pathology*
  • Reperfusion Injury / pathology*
  • Rodentia