Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

Nat Cell Biol. 2018 Jul;20(7):755-765. doi: 10.1038/s41556-018-0133-0. Epub 2018 Jun 27.


Mitochondria sense and respond to many stressors and can support either cell survival or death through energy production and signaling pathways. Mitochondrial responses depend on fusion-fission dynamics that dilute and segregate damaged mitochondria. Mitochondrial motility and inter-organellar interactions, including with the endoplasmic reticulum, also function in cellular adaptation to stress. In this Review, we discuss how stressors influence these components, and how they contribute to the complex adaptive and pathological responses that lead to disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Cell Death
  • Cell Survival
  • Energy Metabolism
  • Humans
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Mitochondrial Dynamics*
  • Signal Transduction
  • Stress, Physiological*