Abstract
The syntheses of some 2-aryl-3-methyl-4,5-dihydro-2H-pyrazolo [4,3-c] quinolin-4-ones and 1-aryl-3-methyl-4,5-dihydro-1H-pyrazolo-[4,5-c] quinolin-4-ones are reported. Some of the latter have shown a high activity in displacing specific [3H]-flunitrazepam binding from bovine brain membranes.
MeSH terms
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Animals
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Binding, Competitive / drug effects
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Brain / metabolism
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Cats
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Chemical Phenomena
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Chemistry
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Flunitrazepam / metabolism
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In Vitro Techniques
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Membranes / metabolism
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Pyrazoles / chemical synthesis*
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Pyrazoles / metabolism
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Pyrazoles / pharmacology
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Quinolines / chemical synthesis*
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Quinolines / metabolism
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Quinolines / pharmacology
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Receptors, GABA-A / metabolism*
Substances
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Pyrazoles
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Quinolines
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Receptors, GABA-A
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Flunitrazepam