Synthesis and binding studies of 1-arylpyrazolo[4,5-c]- and 2-arylpyrazolo[4,3-c]quinolin-4-ones. I

Farmaco Sci. 1985 Jul;40(7):509-16.

Abstract

The syntheses of some 2-aryl-3-methyl-4,5-dihydro-2H-pyrazolo [4,3-c] quinolin-4-ones and 1-aryl-3-methyl-4,5-dihydro-1H-pyrazolo-[4,5-c] quinolin-4-ones are reported. Some of the latter have shown a high activity in displacing specific [3H]-flunitrazepam binding from bovine brain membranes.

MeSH terms

  • Animals
  • Binding, Competitive / drug effects
  • Brain / metabolism
  • Cats
  • Chemical Phenomena
  • Chemistry
  • Flunitrazepam / metabolism
  • In Vitro Techniques
  • Membranes / metabolism
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / metabolism
  • Pyrazoles / pharmacology
  • Quinolines / chemical synthesis*
  • Quinolines / metabolism
  • Quinolines / pharmacology
  • Receptors, GABA-A / metabolism*

Substances

  • Pyrazoles
  • Quinolines
  • Receptors, GABA-A
  • Flunitrazepam