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, 2018, 9064952

Diagnosis of Helicobacter pylori Using Invasive and Noninvasive Approaches


Diagnosis of Helicobacter pylori Using Invasive and Noninvasive Approaches

Amin Talebi Bezmin Abadi. J Pathog.


Helicobacter pylori (H. pylori) as gram-negative and spiral microorganism is responsible for colonization in the gastric microniche for more than 50% of world population. Recent studies have shown a critical role of H. pylori in the development of peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Over the past decade, there has been a sharp interest to use noninvasive tests in diagnosis of the H. pylori infection. During the years after discovery by Marshall and Warren, it has been frequently declared that the rapid urease test (RUT) is one of the cheapest and rapid diagnostic approaches used in detecting the infection. Although the specificity and sensitivity are durable for this test, clinical experiences had shown that the ideal results are only achieved only if we take biopsies from both corpus and antrum at the same time. Given the diagnosis of the H. pylori in clinical samples, gastroenterologists are facing a long list of various molecular and nonmolecular tests. We need more in-depth researches and investigations to correctly generalize rapid and accurate molecular tests determining both bacterial identity and antibiotic resistance profile.


Figure 1
Figure 1
Successful isolation of Helicobacter pylori on Brucella agar supplemented with 5% horse blood.

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    1. Kusters J. G., van Vliet A. H. M., Kuipers E. J. Pathogenesis of Helicobacter pylori infection. Clinical Microbiology Reviews. 2006;19(3):449–490. doi: 10.1128/CMR.00054-05. - DOI - PMC - PubMed
    1. Hu Y., Wan J.-H., Li X.-Y., Zhu Y., Graham D. Y., Lu N.-H. Systematic review with meta-analysis: the global recurrence rate of Helicobacter pylori. Alimentary Pharmacology & Therapeutics. 2017;46(9):773–779. doi: 10.1111/apt.14319. - DOI - PubMed
    1. Polish L. B., Douglas J. M., Jr., Davidson A. J., Perez-Perez G. I., Blaser M. J. Characterization of risk factors for Helicobacter pylori infection among men attending a sexually transmitted disease clinic: Lack of evidence for sexual transmission. Journal of Clinical Microbiology. 1991;29(10):2139–2143. - PMC - PubMed
    1. Schwarz S., Morelli G., Kusecek B., et al. Horizontal versus familial transmission of Helicobacter pylori. PLoS Pathogens. 2008;4(10) doi: 10.1371/journal.ppat.1000180.e1000180 - DOI - PMC - PubMed
    1. Mladenova-Hristova I., Grekova O., Patel A. Zoonotic potential of Helicobacter spp. Journal of Microbiology, Immunology and Infection. 2017;50(3):265–269. doi: 10.1016/j.jmii.2016.11.003. - DOI - PubMed

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