HLA-DR3 and -DR4 control T-lymphocyte responses to mumps and Coxsackie B4 virus: studies on patients with type 1 (insulin-dependent) diabetes and healthy subjects

Diabetologia. 1985 Jul;28(7):420-6. doi: 10.1007/BF00280884.

Abstract

To study the relationships between the responses to viral antigens and the HLA-DR3 and -DR4 associations in Type 1 (insulin-dependent) diabetes mellitus, the frequency of T-lymphocyte proliferating in response to mumps, Coxsackie B4 and varicella-zoster antigens was determined. A decreased frequency was found in T lymphocytes able to respond to mumps or Coxsackie B4 when presented together with DR3, as compared with the frequency of T lymphocytes able to respond to these viruses together with other DR determinants. This was not found for varicella-zoster or purified protein derivative of tuberculin. In contrast, an increased frequency was found in T lymphocytes responding to mumps or Coxsackie B4 together with DR4, compared with other DR determinants. The results were similar in Type 1 diabetic and healthy individuals. The results suggest that elements on the DR3 and DR4 molecules may control T-lymphocyte responses to mumps and Coxsackie B4 viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigen-Presenting Cells / immunology
  • Antigens, Viral / immunology
  • Diabetes Mellitus, Type 1 / immunology*
  • Enterovirus B, Human / immunology*
  • Female
  • HLA-DR Antigens
  • Herpesvirus 3, Human / immunology
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Mumps virus / immunology*
  • T-Lymphocytes / immunology*
  • Tuberculin / immunology

Substances

  • Antigens, Viral
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Tuberculin