Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria

Int J Immunopathol Pharmacol. 2018 Jan-Dec:32:2058738418784431. doi: 10.1177/2058738418784431.


LIGHT (homologous to lymphotoxins, exhibiting inducible expression, and competing with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) has been involved in various autoimmune and inflammatory disorders. LIGHT induces the expression of interleukin-8 (IL-8), which is up-regulated in chronic spontaneous urticaria (CSU). To determine circulating soluble LIGHT concentration and its relationship with IL-8 concentration in patients with CSU. Concentrations of LIGHT, IL-8, and C-reactive protein (CRP) were determined in plasma or serum of CSU patients by an enzyme-linked immunosorbent assay. LIGHT plasma concentration was significantly higher in moderate-severe CSU patients as compared with the healthy subjects, but not with mild CSU patients. There were significant correlations between increased LIGHT and IL-8 concentrations, but not with increased CRP in CSU patients. Enhanced plasma concentrations of soluble LIGHT and its association with IL-8 concentration suggest the role of LIGHT in systemic inflammatory activation in CSU patients. We hypothesize that LIGHT-mediated immune-inflammatory response plays a role in severe phenotypes of the disease.

Keywords: IL-8; LIGHT/TNFSF14; chronic spontaneous urticaria.

MeSH terms

  • Adult
  • C-Reactive Protein / analysis*
  • Case-Control Studies
  • Female
  • Humans
  • Interleukin-8 / blood*
  • Male
  • Middle Aged
  • Severity of Illness Index
  • Solubility
  • Tumor Necrosis Factor Ligand Superfamily Member 14 / blood*
  • Urticaria / blood*
  • Urticaria / immunology
  • Young Adult


  • CXCL8 protein, human
  • Interleukin-8
  • TNFSF14 protein, human
  • Tumor Necrosis Factor Ligand Superfamily Member 14
  • C-Reactive Protein