Organelle dynamics and viral infections: at cross roads

Microbes Infect. Jan-Feb 2019;21(1):20-32. doi: 10.1016/j.micinf.2018.06.002. Epub 2018 Jun 25.

Abstract

Viruses are obligate intracellular parasites of the host cells. A commonly accepted view is the requirement of internal membranous structures for various aspects of viral life cycle. Organelles enable favourable intracellular environment for several viruses. However, studies reporting organelle dynamics upon viral infections are scant. In this review, we aim to summarize and highlight modulations caused to various organelles upon viral infection or expression of its proteins.

Keywords: Ad; Adeno Virus; CMV; Cucumber Mosaic Virus; DENV; Dengue Virus; ER; ERAD; ESCRT; Endoplasmic Reticulum Associated Degradation; Endosomal Sorting Complexes Required for Transport; HBV; HCMV; HCV, Hepatitis C Virus; HFFs; HIV; HSV; Hepatitis B Virus; Herpes Simplex Virus; Huh; Human Cytomegalovirus; Human Foreskin Fibroblasts; Human Hepatoma cell lines; Human Immunodeficiency virus; MMP; MPTP; Mitochondria; Mitochondria Permeability Transition Pore; Mitochondrial Membrane Potential; Nucleus; Organelles; PML NB; PV; Peroxisome; Polio Virus; Promyelocytic Leukemia Nuclear Bodies; ROS; Reactive Oxygen Species; SARS-CoV; SFV; SV40; Semliki Forest Virus; Severe Acute Respiratory Syndrome Corona Virus; Simian Virus; UPR; Unfolded Protein Response; VACV; Vaccinia Virus; Virus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression Regulation
  • Host-Pathogen Interactions*
  • Organelles / pathology
  • Organelles / virology*
  • Viral Proteins / genetics
  • Viral Proteins / metabolism*
  • Virus Diseases / genetics
  • Virus Diseases / metabolism
  • Virus Diseases / virology*
  • Virus Physiological Phenomena*
  • Viruses / genetics
  • Viruses / metabolism

Substances

  • Viral Proteins