Priapism and renal colic in a patient treated with duloxetine

Ment Health Clin. 2016 Jun 29;6(4):197-200. doi: 10.9740/mhc.2016.07.197. eCollection 2016 Jul.


Antidepressant medications are associated with a variety of genitourinary and adverse sexual effects, such as urinary hesitation, priapism, and delayed ejaculation. Here, we report a case of priapism and renal colic following initiation of duloxetine in a patient with history of tolerated selective serotonin reuptake inhibitor treatment. To our knowledge, this represents the first report of priapism and renal colic associated with duloxetine use. This case contributes to the current body of evidence describing adverse genitourinary and sexual effects associated with antidepressant medications.

Keywords: adverse drug reactions; antidepressants; serotonin-norepinephrine reuptake inhibitor; sexual side effects.