Vegetating erosive cutaneous lesions and pyogenic granuloma in the course of mucous membrane pemphigoid: a case report and review of literature

Int Wound J. 2018 Dec;15(6):909-913. doi: 10.1111/iwj.12943. Epub 2018 Jun 29.

Abstract

Mucous membrane pemphigoid (MMP) is a group of chronic autoimmune sub-epithelial blistering disorders, which mostly affect the oral mucosa and the conjunctiva. MMP is very diverse in terms of both the clinical and immunological features (IgG and IgA autoantibodies may react with different antigens). MMP can be induced by infections and medication, including ophthalmologic medication, which may lead to the development of eye lesions. In contrast, a vegetating variant of MMP is extremely rare. Here, we report an MMP case that demonstrated unusual clinical features, that is, pyogenic granulomas on the conjunctivae and extensive vegetating erosions on the skin of intertriginous regions. All these lesions were considered to be induced by unconventional medication containing arsenic.

Keywords: arsenic; immunoblot; laser scanning confocal microscopy; mucous membrane pemphigoid.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Arsenic / adverse effects*
  • Conjunctiva / physiopathology*
  • Female
  • Granuloma, Pyogenic / etiology
  • Granuloma, Pyogenic / therapy*
  • Humans
  • Male
  • Middle Aged
  • Mucous Membrane / physiopathology*
  • Pemphigoid, Benign Mucous Membrane / complications*
  • Pemphigoid, Benign Mucous Membrane / physiopathology*
  • Poland
  • Skin
  • Skin Diseases / etiology
  • Skin Diseases / therapy*
  • Treatment Outcome
  • Wounds and Injuries / etiology
  • Wounds and Injuries / therapy*

Substances

  • Arsenic