The Role of the Anterior Insula in Social Norm Compliance and Enforcement: Evidence From Coordinate-Based and Functional Connectivity Meta-Analyses

Neurosci Biobehav Rev. 2018 Sep;92:378-389. doi: 10.1016/j.neubiorev.2018.06.024. Epub 2018 Jun 26.

Abstract

Economic games -trust (TG) and ultimatum game (UG)- combined with fMRI have shown the importance of the anterior insula (AI) in social normative behaviors. However, whether different AI subregions are engaged in different cognitive and affective processes for social norm compliance and norm enforcement during social exchange remains elusive. Here, we investigated the role of the dorsal AI (dAI) and ventral AI (vAI), combining a coordinate-based meta-analysis of fMRI studies using the TG and UG with meta-analytic task-based and task-free connectivity analyses. Our findings showed that the right dAI and vAI were the only common brain regions consistently activated across games. These clusters were part of two functionally distinguishable connectivity networks associated with cognitive (dAI) and emotional (vAI) processes. In conclusion, we propose that dAI mediates cognitive processes that generate expectancy for norm compliance, whereas vAI mediates aversive feelings that generate motivation to norm enforcement. The identified functional differentiation of the right AI in the social domain contributes to a better understanding of its role in basic and clinical neuroscience.

Keywords: Activation likelihood estimation; Inequity aversion; Meta-analytic connectivity mapping; Norm compliance; Norm enforcement; Resting-state functional connectivity; Trust game; Ultimatum game.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Affect / physiology*
  • Cerebral Cortex / physiology*
  • Cognition / physiology*
  • Economic Competition
  • Humans
  • Social Behavior*
  • Social Norms*