Protein-restricted maternal diet during lactation decreases type I and type III tropocollagen synthesis in the skin of mice offspring

Takumi Yamane; Ryosuke Konno; Ken Iwatsuki; Yuichi Oishi

doi:10.1080/09168451.2018.1491288

Protein-restricted maternal diet during lactation decreases type I and type III tropocollagen synthesis in the skin of mice offspring

Biosci Biotechnol Biochem. 2018 Oct;82(10):1829-1831. doi: 10.1080/09168451.2018.1491288. Epub 2018 Jul 2.

Authors

Takumi Yamane¹, Ryosuke Konno¹, Ken Iwatsuki¹, Yuichi Oishi¹

Affiliation

¹ a Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Setagaya-ku Tokyo , Japan.

PMID: 29961398
DOI: 10.1080/09168451.2018.1491288

Abstract

We investigated the effects of a low protein (LP) maternal diet during lactation on type I and III tropocollagen synthesis in infant mouse skin. The LP diet decreased the levels of type I and III tropocollagen proteins and COL1A1 and COL3A1 mRNA. Thus, the protein composition of the maternal perinatal diet may influence the skin health of offspring.

Keywords: Skin; collagen; lactation; protein malnutrition.

MeSH terms

Animals
Body Weight
Collagen Type I / biosynthesis*
Collagen Type I / genetics
Collagen Type III / biosynthesis*
Diet, Protein-Restricted
Dietary Proteins / administration & dosage*
Female
Lactation*
Mice, Inbred C57BL
RNA, Messenger / genetics
Skin / metabolism*
Tropocollagen / biosynthesis*
Tropocollagen / genetics

Substances

Collagen Type I
Collagen Type III
Dietary Proteins
RNA, Messenger
Tropocollagen