Structure of the human interleukin-2 receptor gene

Science. 1985 Nov 8;230(4726):633-9. doi: 10.1126/science.2996141.

Abstract

The gene encoding the human interleukin-2 (IL-2) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement factor B. Alternative messenger RNA (mRNA) splicing may delete exon 4 sequences, resulting in a mRNA that does not encode a functional IL-2 receptor. Leukemic T cells infected with HTLV-I and normal activated T cells express IL-2 receptors with identical deduced protein sequences. Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • Complement Factor B / genetics
  • DNA / genetics
  • DNA / isolation & purification
  • DNA, Recombinant / isolation & purification
  • Deltaretrovirus
  • Genes, MHC Class II*
  • Humans
  • Peptide Chain Initiation, Translational
  • RNA, Messenger / genetics
  • Receptors, Immunologic / biosynthesis
  • Receptors, Immunologic / genetics*
  • Receptors, Interleukin-2
  • Repetitive Sequences, Nucleic Acid
  • Retroviridae Infections / genetics
  • T-Lymphocytes / microbiology
  • Transcription, Genetic

Substances

  • DNA, Recombinant
  • RNA, Messenger
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • DNA
  • Complement Factor B

Associated data

  • GENBANK/M10322
  • GENBANK/M11060
  • GENBANK/M11061
  • GENBANK/M11062
  • GENBANK/M11063
  • GENBANK/M11064
  • GENBANK/M11065
  • GENBANK/M11066