Botulinum Toxin: Techniques Within Pediatric Physiatry

PM R. 2019 Jan;11(1):38-44. doi: 10.1016/j.pmrj.2018.06.004. Epub 2019 Jan 22.

Abstract

Background: Intramuscular botulinum toxin injections are used for treatment of focal spasticity in children, particularly in those with a diagnosis of cerebral palsy. There are a variety of techniques used when performing botulinum toxin injections without clear standards for pediatric providers.

Objective: To describe current practice techniques for botulinum toxin injections among pediatric physiatrists.

Design: Cross-sectional survey using RedCap Software.

Setting: Pediatric physiatrists who perform botulinum toxin injections.

Participants: Survey of 307 pediatric physiatrists.

Methods: Analysis of data from the 2017 practice survey of pediatric physiatrists in the United States.

Main outcome measurements: Physicians were asked the primary botulinum toxin used, common dosing information, the role of localization, and the role of sedation and distraction in their practice.

Results: Nearly all pediatric physiatrists use OnabotulinumtoxinA as the primary formulation of botulinum toxin. The maximum dose per body weight used per injection series had a median of 15 units/kilogram and a median maximum total dose of 500 units. Sixty-five percent of pediatric physiatrists report using sedation, of any type, for botulinum toxin injections. When using sedation, the most common primary method was general anesthesia (38.9%), followed by enteral or nasal anxiolytic with the patient awake (26.2%). The most common reported intended injection site for botulinum toxin was "in multiple sites spread throughout the muscle" (67.9%), and then "one site of the muscle at the motor point" (17.1%). Large muscles were injected using primarily anatomic guidance (75.6%) and electromyography (50.8%), and small muscles were primarily completed with electromyography (73.6%) and anatomic guidance (49.2%).

Conclusion: There is considerable variability present in one common procedure performed by pediatric physiatrists.

Level of evidence: NA.

MeSH terms

  • Adolescent
  • Botulinum Toxins, Type A / administration & dosage*
  • Cerebral Palsy / diagnosis
  • Cerebral Palsy / drug therapy*
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Electromyography / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Hypnotics and Sedatives / administration & dosage
  • Injections, Intramuscular
  • Male
  • Muscle Spasticity / diagnosis
  • Muscle Spasticity / drug therapy
  • Neuromuscular Agents / administration & dosage
  • Pediatrics
  • Physiatrists / trends
  • Practice Patterns, Physicians' / trends
  • Surveys and Questionnaires*
  • Treatment Outcome
  • United States

Substances

  • Hypnotics and Sedatives
  • Neuromuscular Agents
  • Botulinum Toxins, Type A
  • onabotulinum toxin A