Macropinocytosis Fuels Prostate Cancer

Cancer Discov. 2018 Jul;8(7):800-802. doi: 10.1158/2159-8290.CD-18-0513.


Kim and colleagues identify necrotic debris as a macropinocytic cargo in PTEN-deficient prostate cancer cells, which is catabolized to generate the nutrients and biomass necessary to support tumor cell growth and metabolism in nutrient-limiting conditions. Cancer Discov; 8(7); 800-2. ©2018 AACR.See related article by Kim et al., p. 866.

Publication types

  • Comment

MeSH terms

  • AMP-Activated Protein Kinases
  • Humans
  • Male
  • Nutrients*
  • PTEN Phosphohydrolase
  • Prostatic Neoplasms*


  • AMP-Activated Protein Kinases
  • PTEN Phosphohydrolase
  • PTEN protein, human