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Randomized Controlled Trial
, 28 (11), 3454-3465

Changes in Bone Mineral Density Following Weight Loss Induced by One-Anastomosis Gastric Bypass in Patients With Vitamin D Supplementation

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Randomized Controlled Trial

Changes in Bone Mineral Density Following Weight Loss Induced by One-Anastomosis Gastric Bypass in Patients With Vitamin D Supplementation

Maria Luger et al. Obes Surg.

Abstract

Background: Little is known about changes in bone mineral density (BMD) following weight loss after one-anastomosis gastric bypass (OAGB) and the role of serum vitamin D and its supplementation on bone metabolism. We evaluated BMD after OAGB as a function of vitamin D supplementation with respect to a minimum threshold of 25-hydroxy-vitamin-D [25(OH)D] concentration, which could prevent or decelerate an eventual bone loss.

Methods: Fifty bariatric patients who participated in the randomized controlled trial were included in this analysis. BMD and anthropometric measurements by DXA and laboratory parameters were assessed before (T0), at 6 (T6), and 12 months (T12) after surgery.

Results: OAGB resulted in a 36% total body weight loss with a decrease in body fat and an increase in lean body mass. A significant decrease in BMD was seen in lumbar spine by 7%, left hip 13%, and total body 1%, but not in forearm. Bone turnover markers increased significantly but with normal parathyroid hormone concentrations. Weight loss was not associated with changes in BMD. A serum 25(OH)D concentration > 50 nmol/l at T6 and T12 (adequate-vitamin-D-group; AVD) showed a significant lower bone loss, compared to the inadequate-vitamin-D-group (IVD; < 50 nmol/l). Lower bone loss in the left hip showed a strong correlation with higher 25(OH)D concentrations (r = 0.635, p = 0.003).

Conclusion: These findings support a dose effect of vitamin D supplementation on bone health and suggest that 25(OH)D concentrations need to be above 50 nmol/l at least during the first postoperative year to decelerate bone loss in patients undergoing OAGB.

Clinical trial registry number and website: Clinicaltrials.gov (NCT02092376) at https://clinicaltrials.gov /. EudraCT (2013-003546-16) at https://eudract.ema.europa.eu /.

Keywords: Bone loss; Obesity; One-anastomosis gastric bypass; Vitamin D; Weight loss.

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References

    1. Obes Surg. 2001 Jun;11(3):276-80 - PubMed
    1. Obes Surg. 2017 Aug;27(8):2194-2206 - PubMed
    1. Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235 - PubMed
    1. J Clin Endocrinol Metab. 2004 Mar;89(3):1061-5 - PubMed
    1. Braz J Med Biol Res. 2007 Apr;40(4):509-17 - PubMed

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