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. 2018 Nov;62(2):340-350.
doi: 10.1007/s12020-018-1658-5. Epub 2018 Jul 2.

Sentinel Lymph Node Biopsy in Small Papillary Thyroid Cancer. A Review on Novel Surgical Techniques


Sentinel Lymph Node Biopsy in Small Papillary Thyroid Cancer. A Review on Novel Surgical Techniques

Ludovico Maria Garau et al. Endocrine. .


Purpose: Sentinel lymph node biopsy (SNB) in patients with papillary thyroid carcinoma (PTC) and negative for clinically neck lymph node metastatic involvement (N0) has emerged as a promising minimally invasive procedure to detect metastatic nodes.

Methods: The MEDLINE database was searched via the PubMed interface on 10 January 2018 for the MeSH headings "sentinel lymph node biopsy" and "thyroid carcinoma".

Results: Vital blue dye, radioisotope, and the combination of both techniques are used in PTC patients. These methods and the emerging role of SPECT/CT are discussed in this review. The sentinel lymph node (SLN) identification rates ranged from 0 to 100% for blue dye, 83 to 100% for radioisotopes, and 66 to 100% for the combination of both techniques, respectively.

Conclusions: SNB based on radioisotope technique with the use of intraoperative gamma-probe is an accurate and safe method that allows the highest SLN detection rate. There is sufficient evidence to propagate the increasing use of SNB procedure that has the potential to avoid prophylactic lymph node surgery in patients clinically N0.

Keywords: Gamma-probe technique; Lymphoscintigraphy; Sentinel lymph node biopsy; Thyroid carcinoma; Vital blue dye technique.

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