Dewaxed Brown Rice Feed Improves Fatty Liver in Obese and Diabetic Model Mice

Anticancer Res. 2018 Jul;38(7):4339-4345. doi: 10.21873/anticanres.12734.


Background/aim: Dewaxed brown rice has macrophage activation ability via TLR4 and contains a high amount of lipopolysaccharides (LPS). It is expected that dewaxed brown rice can help prevent lifestyle diseases. In this study, the anti-obesity effect of dewaxed brown rice was investigated using obese and diabetic model mice.

Materials and methods: Dewaxed brown rice and white rice were polished and powdered by Toyo Rice Co. Diet pellets were prepared (AIN-93) with 50% dewaxed brown rice or white rice powder and fed to type II diabetic model KK-Ay mice for 10 weeks. Weight and fasting blood glucose were measured every week, and whole blood and liver was collected on the final day for the evaluation of biochemical data.

Results: A 20% reduction in body weight was found in the dewaxed brown rice feed and white rice feed groups compared to the normal feed group. Fasting blood glucose increased in the normal-diet group, but on the other hand, the blood glucose in the white rice and the dewaxed brown rice feed group was almost constant. Dewaxed brown rice feed group of plasma ALT and AST, liver TG and T-CHO were significantly lower than that of the control and the white rice feed group.

Conclusion: Dewaxed brown rice feed has an anti-obesity effect to suppress increasing body weight, fasting blood glucose, and an effect of suppressing fatty liver.

Keywords: Brown rice; fatty liver; lipopolysaccharides.

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2*
  • Diet
  • Disease Models, Animal
  • Fatty Liver*
  • Female
  • Food Handling / methods
  • Mice
  • Obesity*
  • Oryza* / chemistry