Promotion of Insulin-like growth factor II in cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma

J Cancer Res Ther. 2018;14(4):844-850. doi: 10.4103/jcrt.JCRT_605_17.


Aim: This study aims to investigate the involvement of insulin-like growth factor II (IGF-II) in human hepatocellular carcinoma (HCC) proliferation and metastasis.

Materials and methods: The effects of IGF-II on cell proliferation, cell cycle, apoptosis, cell migration, and invasion in HCC Huh7 cells were investigated in the study.

Results: IGF-II promoted cell proliferation and colony formation, suppressed cell apoptosis in Huh7 cells by promoting cell cycle progression, induced epithelial-mesenchymal transition (EMT) phenotypes, and enhanced the metastatic potential of HCC in vitro.

Conclusion: Our results revealed that IGF-II promotes cell proliferation and EMT in HCC cells.

Keywords: Cell proliferation; epithelial–mesenchymal transition; hepatocellular carcinoma; insulin-like growth factor II; metastasis.

MeSH terms

  • Apoptosis
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / pathology*
  • Cell Cycle / genetics
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Epithelial-Mesenchymal Transition / genetics*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Insulin-Like Growth Factor II / genetics*
  • Insulin-Like Growth Factor II / metabolism
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology*
  • Neoplasm Metastasis
  • Signal Transduction / drug effects


  • Insulin-Like Growth Factor II