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A Randomised Controlled Trial to Evaluate the Plaque Removal Efficacy of Sodium Bicarbonate Dentifrices in a Single Brushing Clinical Model

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A Randomised Controlled Trial to Evaluate the Plaque Removal Efficacy of Sodium Bicarbonate Dentifrices in a Single Brushing Clinical Model

Mary-Lynn Bosma et al. BDJ Open.

Abstract

Objective: To evaluate plaque removal efficacy of dentifrices containing sodium bicarbonate (NaHCO3) compared with a non-NaHCO3 dentifrice after a single-timed brushing.

Materials and methods: A randomised, controlled, examiner-blinded, four-period, crossover study in 56 adults with a mean whole-mouth plaque index of ≥2.00 (six site modification of Turesky modification of Quigley-Hein Plaque Index [TPI]). Subjects brushed once for one timed minute with a 67% NaHCO3 dentifrice with herbs; a 67% NaHCO3 dentifrice without herbs; a 62% NaHCO3 dentifrice with herbs; or a non-NaHCO3 dentifrice without herbs. All contained 923 p.p.m. fluoride as sodium fluoride. Pre- and post-brushing plaque assessments were performed.

Results: Mean TPI score decreased from pre- to post-brushing with all treatments. There were statistically significantly greater reductions in plaque for NaHCO3 dentifrices compared to non-NaHCO3 (p < 0.0001 for all) with no significant differences between NaHCO3-containing dentifrices. A post hoc analysis of plaque removal from different oral areas showed statistically significant differences in favour of the NaHCO3 dentifrices over the non-NaHCO3 dentifrice for almost all surfaces. No adverse events were reported.

Discussion and conclusion: Plaque removal was significantly greater with NaHCO3-containing dentifrices compared with a non-NaHCO3 dentifrice after a single, timed brushing. There was no effect of herbal tinctures. This study was registered at ClincalTrials.org: NCT03285984.

Conflict of interest statement

I.A., D.T. and M-L.B. have no conflicts of interest. J.L.M. and K.R.M. are employees of Salus Research, Inc., which has received funding from GSK Consumer Healthcare. K.R.M. has received funding from GSK Consumer Healthcare as a consultant.

Figures

Fig. 1
Fig. 1
Raw mean whole-mouth TPI score (±SE) at baseline and post-brushing (ITT population). Scores range from 0 (no plaque) to 5 (plaque covering ≥2/3 of the crown of the tooth)
Fig. 2
Fig. 2
Change from baseline in adjusted mean whole-mouth TPI score (±SE) (ITT population). Scores range from 0 (no plaque) to 5 (plaque covering ≥2/3 of the crown of the tooth)

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References

    1. Whiley RA, Beighton D. Current classification of the oral streptococci. Oral Microbiol. Immunol. 1998;13:195–216. doi: 10.1111/j.1399-302X.1998.tb00698.x. - DOI - PubMed
    1. La Placa M, Ghersetich I. Infections of the oral cavity. In: Lotti T, Parish LC, Rogers RS III, editors. Oral diseases: Textbook and atlas. Berlin: Springer-Verlag; 1999. pp. 77–128.
    1. Chapple IL, et al. Primary prevention of periodontitis: managing gingivitis. J. Clin. Periodontol. 2015;42(Suppl 16):S71–76. doi: 10.1111/jcpe.12366. - DOI - PubMed
    1. Mankodi S, Berkowitz H, Durbin K, Nelson B. Evaluation of the effects of brushing on the removal of dental plaque. J. Clin. Dent. 1998;9:57–60. - PubMed
    1. Newbrun E. The use of sodium bicarbonate in oral hygiene products and practice. Comp. Cont. Educ. Dent. Supp. 1997;18:S2–S7. - PubMed

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