Recent advances in cytogenetic characterization of multiple myeloma

Int J Lab Hematol. 2019 Feb;41(1):5-14. doi: 10.1111/ijlh.12882. Epub 2018 Jul 3.

Abstract

The detection of cytogenetic abnormalities in multiple myeloma (MM) has received more importance over last years for risk stratification and the new risk-adapted treatment strategies. Conventional G-banding analysis should be included in a routine procedure for the initial diagnostic workup for patients suspected of MM. However, the detection of chromosomal abnormalities in MM by conventional cytogenetics is limited owing to the low proliferative activity of malignant plasma cells as well as the low number of plasma cells in bone marrow specimens. Fluorescence in situ hybridization (FISH) or microarray-based technologies can overcome some of those drawbacks and detect specific target arrangements as well as chromosomal copy number changes. In this review, we will discuss different cytogenetic approaches and compare their strength and weakness to provide genetic information for risk stratification and prediction of outcome in MM patients.

Keywords: chromosome abnormalities; cytogenetics; fluorescence in situ hybridization; microarray; multiple myeloma.

Publication types

  • Review

MeSH terms

  • Chromosome Aberrations
  • Cytogenetics / methods*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Multiple Myeloma / genetics*
  • Risk Assessment
  • Tissue Array Analysis

Grant support