Noncoding RNAs in disease

FEBS Lett. 2018 Sep;592(17):2884-2900. doi: 10.1002/1873-3468.13182. Epub 2018 Jul 20.


Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In this Mini-Review, we highlight a selection of studies in order to demonstrate the wide-scale involvement of miRNAs and long noncoding RNAs in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches.

Keywords: long noncoding RNA; microRNA; noncoding RNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cardiovascular Diseases / genetics*
  • Gene Expression Regulation
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Neoplasms / genetics*
  • Nervous System Diseases / genetics*
  • RNA, Long Noncoding / genetics*
  • RNA, Untranslated / genetics*


  • RNA, Long Noncoding
  • RNA, Untranslated