Neoadjuvant chemotherapy for breast cancer-background for the indication of locoregional treatment

Strahlenther Onkol. 2018 Sep;194(9):797-805. doi: 10.1007/s00066-018-1329-8. Epub 2018 Jul 4.

Abstract

Neoadjuvant chemotherapy (NACT) has been widely adopted into the multidisciplinary management of breast cancer. The prognostic impact of treatment response has been clearly demonstrated. However, the impact of treatment response on the indication for adjuvant radiotherapy is unclear. This review summarizes important implications of NACT and treatment response on the risk of recurrence and locoregional multidisciplinary management from the standpoint of radiation oncology.

Keywords: Neoadjuvant treatment; Neoplasm recurrence, local; Post-mastectomy radiotherapy; Regional nodal irradiation; Sentinel lymph node biopsy.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Chemotherapy, Adjuvant / methods*
  • Combined Modality Therapy
  • Disease-Free Survival
  • Follow-Up Studies
  • Humans
  • Interdisciplinary Communication
  • Intersectoral Collaboration
  • Mastectomy*
  • Neoadjuvant Therapy / methods*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Neoplasm, Residual / pathology
  • Neoplasm, Residual / therapy
  • Prognosis
  • Radiotherapy, Adjuvant*
  • Sentinel Lymph Node Biopsy