A Cytoskeletal Symphony: Owed to TOG

Dev Cell. 2018 Jul 2;46(1):5-7. doi: 10.1016/j.devcel.2018.06.010.


Like permutating motifs in music, similar protein folds are employed across biology for distinct functions. In this issue of Developmental Cell, Aher et al. (2018) provide insight into how variable TOG domains within an array in the microtubule regulator CLASP are used to prevent microtubule catastrophe and potentiate rescue.

Publication types

  • Comment

MeSH terms

  • Amino Acid Sequence
  • Microtubule-Associated Proteins*
  • Microtubules
  • Models, Molecular
  • Tubulin*


  • Microtubule-Associated Proteins
  • Tubulin