Abstract
A beta-adrenergic blocking activity of perhexiline was compared with that of propanolol. In the Langendorff's preparation of rabbits, canine heart-lung preparations, open-chest dog preparations and hind-limbs of dogs, perhexiline failed to block isoproterenol-induced changes in cardiovascular functions, which were effectively blocked by propranolol. These data suggest that perhexiline is not a beta-adrenergic receptor blocking agent.
MeSH terms
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Adrenergic beta-Antagonists / pharmacology
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Animals
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Blood Pressure / drug effects
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Cardiac Output / drug effects
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Dogs
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Female
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Heart Rate / drug effects
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Hemodynamics / drug effects*
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In Vitro Techniques
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Isoproterenol / antagonists & inhibitors*
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Male
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Myocardial Contraction / drug effects
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Perhexiline / pharmacology*
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Piperidines / pharmacology*
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Propranolol / pharmacology*
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Rabbits
Substances
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Adrenergic beta-Antagonists
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Piperidines
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Propranolol
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Perhexiline
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Isoproterenol