Cardiovascular effects of isoproterenol and possible antagonistic actions of propranolol and perhexiline

Jpn Circ J. 1978 Apr;42(4):425-32. doi: 10.1253/jcj.42.425.

Abstract

A beta-adrenergic blocking activity of perhexiline was compared with that of propanolol. In the Langendorff's preparation of rabbits, canine heart-lung preparations, open-chest dog preparations and hind-limbs of dogs, perhexiline failed to block isoproterenol-induced changes in cardiovascular functions, which were effectively blocked by propranolol. These data suggest that perhexiline is not a beta-adrenergic receptor blocking agent.

Publication types

  • Comparative Study

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology
  • Animals
  • Blood Pressure / drug effects
  • Cardiac Output / drug effects
  • Dogs
  • Female
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • In Vitro Techniques
  • Isoproterenol / antagonists & inhibitors*
  • Male
  • Myocardial Contraction / drug effects
  • Perhexiline / pharmacology*
  • Piperidines / pharmacology*
  • Propranolol / pharmacology*
  • Rabbits

Substances

  • Adrenergic beta-Antagonists
  • Piperidines
  • Propranolol
  • Perhexiline
  • Isoproterenol